Article
Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation.
Cellular immunology - 1 Jan 2010
Noman Abu Shadat Mohammod, Koide Naoki, Iftakhar-E-Khuda Imtiaz, Dagvadorj Jargalsaikhan, Tumurkhuu Gantsetseg, Naiki Yoshikazu, Komatsu Takayuki, Yoshida Tomoaki, Yokochi Takashi
Abstract excerpt
The involvement of retinoblastoma protein-interacting zinc finger 1 (RIZ1), a tumor suppressor, in lipopolysaccharide (LPS)-induced inflammatory responses was investigated by using RAW 264.7 macrophage-like cells. LPS significantly augmented the expression of RIZ1 and the augmentation was mediated by the activation of nuclear factor (NF)-kappaB and Akt. The silencing of RIZ1 with the siRNA led to the inactivation...
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