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Article

MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2014

Lin Ren-Jye, Chu Jan-Show, Chien Hsu-Ling, Tseng Chung-Hsin, Ko Pin-Chen, Mei Yung-Yu, Tang Wei-Chun, Kao Yu-Ting, Cheng Hui-Ying, Liang Yu-Chih, Lin Shyr-Yi

Abstract excerpt

Human MCP-1-induced protein 1 (MCPIP1, also known as ZC3H12A and Regnase-1) plays important roles in negatively regulating the cellular inflammatory response. Recently, we found that as an RNase, MCPIP1 has broad-spectrum antiviral effects by targeting viral RNA. In this study, we demonstrated that MCPIP1 expression was induced by hepatitis C virus (HCV) infection in Huh7.5 hepatoma cells. MCPIP1 expression was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25225661
DOI: 10.4049/jimmunol.1400337

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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