Article

Investigating NF-κB ubiquitination : an in vitro study

2019-01-01

Abstract excerpt

NF-κB is a transcription factor family that controls the expression of hundreds of biologically important genes, many of which have essential roles in the regulation of inflammation. When its activity is dysregulated, this can lead to the development of chronic inflammatory diseases such as rheumatoid arthritis. Therefore, it is critical that NF-κB is tightly controlled. The p50 subunit of NF-κB lacks a transactiv...

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Literature Corpus work: d5f258fc-6459-5574-aa58-b995e5eb82fd
DOI: 10.5525/gla.thesis.74343

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