Article
Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese.
Carcinogenesis - 1 Feb 2008
Furue Hiroki, Matsuo Keitaro, Kumimoto Hiroshi, Hiraki Akio, Suzuki Takeshi, Yatabe Yasushi, Komori Koji, Kanemitsu Yukihide, Hirai Takashi, Kato Tomoyuki, Ueda Minoru, Ishizaki Kanji, Tajima Kazuo
Abstract excerpt
BACKGROUND: NKG2D is an immune receptor on natural killer (NK) and other cells active in the immune system. It recognizes ligands expressed on mainly transformed cells and plays a role in their elimination through the so-called 'cancer immune surveillance'. It was reported that there are two haplotypes of NKG2D, HNK1 (high NK activity) and LNK1 (low NK activity). Harboring the HNK1 is reported to reduce the...
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