A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers.

doi:10.1038/srep39231

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Article

A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers.

Scientific reports - 20 Dec 2016

Espinoza J Luis, Nguyen Viet H, Ichimura Hiroshi, Pham Trang T T, Nguyen Cuong H, Pham Thuc V, Elbadry Mahmoud I, Yoshioka Katsuji, Tanaka Junji, Trung Ly Q, Takami Akiyoshi, Nakao Shinji

Abstract excerpt

Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide and is etiologically linked to several cancers, including cervical and genital cancers. NKG2D, an activating receptor expressed by NK cells, plays an important role in cancer immune-surveillance. We analyzed the impact of a NKG2D gene variant, rs1049174, on the incidence of HPV-related cancers in Vietnamese patients and utilized...

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PMID: 27995954
DOI: 10.1038/srep39231
PMCID: PMC5172372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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