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Article

ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.

Human molecular genetics - 1 Apr 2008

Herb Florian, Thye Thorsten, Niemann Stefan, Browne Edmund N L, Chinbuah Margaret A, Gyapong John, Osei Ivy, Owusu-Dabo Ellis, Werz Oliver, Rüsch-Gerdes Sabine, Horstmann Rolf D, Meyer Christian G

Abstract excerpt

The 5-lipoxygenase (ALOX5)-derived lipid mediators leukotrienes and lipoxins have regulatory functions in inflammation by modulating activities of immune cells and cytokine production. Recently, it was shown in ALOX5-/- mice that host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase (5-LO). ALOX5 polymorphisms were genotyped in 1916 sputum-positive patients with pulmonary tuberculosis (TB)...

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Source

Identifiers

PMID: 18174194
DOI: 10.1093/hmg/ddm378

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.PMID 18174194Read ↗

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Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.Semantic proximity Read ↗

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