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Article

A genetic variant in the TRAF1/C5 gene lead susceptibility to active pulmonary tuberculosis by decreased TNF-α levels.

Microbial pathogenesis - 1 Oct 2021

Souza de Lima Dhêmerson, Fadoul de Brito Carolina, Cavalcante Barbosa Aguyda Rayany, Brasil de Andrade Figueira Mariana, Maciel Bonet Julio César, Walzer Joseph, Ramasawmy Rajendranath, Ogusku Mauricio Morishi, Sadahiro Aya, Boechat Antonio Luiz

Abstract excerpt

Host genetics are important to consider in the role of resistance or susceptibility for developing active pulmonary tuberculosis (TB). Several association studies have reported the role of variants in STAT4 and TRAF1/C5 as risk factors to autoimmune diseases. Nevertheless, more data is needed to elucidate the role of these gene variants in infectious disease. Our data reports for the first time, variant...

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Share to Complement C5
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to TNF Receptor-Associated Factor 1

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Identifiers

PMID: 34363926
DOI: 10.1016/j.micpath.2021.105117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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