Article
Maximum likelihood estimates of two-locus recombination fractions under some natural inequality restrictions.
BMC genetics - 4 Jan 2008
Zhou Ying, Shi Ning-Zhong, Fung Wing-Kam, Guo Jianhua
Abstract excerpt
BACKGROUND: The goal of linkage analysis is to determine the chromosomal location of the gene(s) for a trait of interest such as a common disease. Three-locus linkage analysis is an important case of multi-locus problems. Solutions can be found analytically for the case of triple backcross mating...
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