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A statistical measure for the skewness of X chromosome inactivation based on family trios

1 Dec 2018

Abstract excerpt

BACKGROUND: X chromosome inactivation (XCI) is an important gene regulation mechanism in females to equalize the expression levels of X chromosome between two sexes. Generally, one of two X chromosomes in females is randomly chosen to be inactivated. Nonrandom XCI (XCI skewing) is also observed in females, which has been reported to play an important role in many X-linked diseases. However, there is no...

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PMID: 30518319
DOI: 10.1186/s12863-018-0694-8

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