Two- and three-locus tests for linkage analysis using recombinant inbred lines.

doi:10.1534/genetics.105.047175

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Article

Two- and three-locus tests for linkage analysis using recombinant inbred lines.

Genetics - 1 May 2006

Martin Olivier C, Hospital Frédéric

Abstract excerpt

We consider fixed recombinant inbred lines (RILs) derived either by selfing or by full-sib mating; when applicable, we also consider intermated recombinant inbreds (IRIs). First, we show that the usual estimate of recombination fraction based on RIL data is biased, and we provide an estimate where the major part of that bias is removed. Second, we derive simple formulas to compute the frequencies of genotypes at...

Topics

Chromosome Mapping
Genetic Linkage
Genotype
Inbreeding
Models, Genetic
Quantitative Trait Loci
Recombination, Genetic

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Identifiers

PMID: 16489236
DOI: 10.1534/genetics.105.047175
PMCID: PMC1461428

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