Mutation of RAS oncogene in atomic bomb radiation-exposed leukemia.

Abstract excerpt

To determine what the role of RAS oncogene is in radiation-induced leukemia, we investigated the frequency of mutations and the sites of the base substitution of activated N- and K-RAS oncogenes in 25 leukemic patients who had been exposed to the atomic bomb and compared the results with those for 47 non-exposed leukemic patients. To detect the presence of mutated RAS oncogene, we used the PCR method to analyze...

Topics

• Base Sequence
• Genes, ras
• Humans
• Leukemia, Radiation-Induced
• Molecular Sequence Data
• Mutation
• Nuclear Warfare