Article
Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents.
Carcinogenesis - 1 May 2004
Barletta Emanuela, Gorini Giuseppe, Vineis Paolo, Miligi Lucia, Davico Laura, Mugnai Gabriele, Ciolli Stefania, Leoni Franco, Bertini Marilena, Matullo Giuseppe, Costantini Adele Seniori
Abstract excerpt
Mutations of the N- and K-ras genes occur in approximately 15-30% of acute myeloid leukaemia patients. The role of the oncogenic ras in leukaemogenesis remains unclear. Few studies have revealed that mutations in the ras oncogene family are more probably found in acute myeloid leukaemia patients with previous exposure to toxic agents. A case-case study was conducted in the areas of Florence and Turin, Italy, to...
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