Article
A leptin-regulated circuit controls glucose mobilization during noxious stimuli.
The Journal of clinical investigation - 1 Aug 2017
Flak Jonathan N, Arble Deanna, Pan Warren, Patterson Christa, Lanigan Thomas, Goforth Paulette B, Sacksner Jamie, Joosten Maja, Morgan Donald A, Allison Margaret B, Hayes John, Feldman Eva, Seeley Randy J, Olson David P, Rahmouni Kamal, Myers Martin G
Abstract excerpt
Adipocytes secrete the hormone leptin to signal the sufficiency of energy stores. Reductions in circulating leptin concentrations reflect a negative energy balance, which augments sympathetic nervous system (SNS) activation in response to metabolically demanding emergencies. This process ensures adequate glucose mobilization despite low energy stores. We report that leptin receptor-expressing neurons (LepRb...
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