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Article

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.

PloS one - 2 Jan 2008

Hao Yi-Heng, Wang Yong, Burdette Dara, Mukherjee Sohini, Keitany Gladys, Goldsmith Elizabeth, Orth Kim

Abstract excerpt

MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent activation by phosphorylation. YopJ is also able to block yeast MAPK signaling pathways using this mechanism. Based on these observations, we performed a genetic screen to isolate mutants in the yeast MKK, Pbs2, that...

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Share to Acetylation
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Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

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Source

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Identifiers

PMID: 18167536
DOI: 10.1371/journal.pone.0001375
PMCID: PMC2147050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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