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Article

Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism.

Cellular microbiology - 1 Jan 2003

Deleuil Fabienne, Mogemark Lena, Francis Matthew S, Wolf-Watz Hans, Fällman Maria

Abstract excerpt

The tyrosine phosphatase YopH is an essential virulence factor produced by pathogenic Yersinia species. YopH is translocated into host cells via a type III secretion system and its dephosphorylating activity causes disruption of focal complex structures and blockage of the phagocytic process. Among the host cell targets of YopH are the focal adhesion proteins Crk-associated substrate (p130Cas) and focal adhesion...

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Source

Identifiers

PMID: 12542470
DOI: 10.1046/j.1462-5822.2003.00236.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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