Article
Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion.
The European respiratory journal - 1 Jan 2008
Hamidi S A, Prabhakar S, Said S I
Abstract excerpt
The pathogenesis of idiopathic pulmonary arterial hypertension (PAH) remains poorly understood. The present authors recently reported that mice with vasoactive intestinal peptide (VIP) gene disruption show a spontaneous phenotype of PAH, with pulmonary vascular remodelling and lung inflammation. To explore the underlying molecular mechanisms in this model, it was examined whether absence of the VIP gene might...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.