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Article

VIP gene deletion in mice causes cardiomyopathy associated with upregulation of heart failure genes.

PloS one - 1 Jan 2013

Szema Anthony M, Hamidi Sayyed A, Smith S David, Benveniste Helene

Abstract excerpt

RATIONALE: Vasoactive Intestinal Peptide (VIP), a pulmonary vasodilator and inhibitor of vascular smooth muscle proliferation, is absent in pulmonary arteries of patients with idiopathic pulmonary arterial hypertension (PAH). We previously determined that targeted deletion of the VIP gene in mice leads to PAH with pulmonary vascular remodeling and right ventricular (RV) dilatation. Whether the left ventricle is...

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Source

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Identifiers

PMID: 23700405
DOI: 10.1371/journal.pone.0061449
PMCID: PMC3659051

Genes

VIP
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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