Article
Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease.
Peptides - 1 Sept 2007
Lelievre V, Favrais G, Abad C, Adle-Biassette H, Lu Y, Germano P M, Cheung-Lau G, Pisegna J R, Gressens P, Lawson G, Waschek J A
Abstract excerpt
In 1970, Drs. Said and Mutt isolated a novel peptide from porcine intestinal extracts with powerful vasoactive properties, and named it vasoactive intestinal peptide (VIP). Since then, the biological actions of VIP in the gut as well as its signal transduction pathways have been extensively studied. A variety of in vitro and in vivo studies have indicated that VIP, expressed in intrinsic non-adrenergic...
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