Article
Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin.
Human mutation - 1 Mar 2008
Abdel-Rahman Wael M, Kalinina Juliya, Shoman Soheir, Eissa Saad, Ollikainen Miina, Elomaa Outi, Eliseenkova Anna V, Bützow Ralf, Mohammadi Moosa, Peltomäki Päivi
Abstract excerpt
We previously described striking molecular features including high frequency of membranous beta-catenin in subsets of familial colon cancers with as yet unknown predisposition. We hypothesized that such tumors might carry mutations in Wnt/beta-catenin target genes. Fibroblast growth factor 9 (FGF9) was an attractive target, as it maps to a common area of loss of heterozygosity (LOH) in colorectal carcinomas on...
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