Article
XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study.
International journal of cancer - 15 Jun 2009
Zhou Keke, Liu Yanhong, Zhang Haishi, Liu Hongliang, Fan Weiwei, Zhong Yu, Xu Zhonghui, Jin Li, Wei Qingyi, Huang Fengping, Lu Daru, Zhou Liangfu
Abstract excerpt
In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype-based approach to investigate whether 4 tagging single nucleotide polymorphisms of the...
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