Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.

doi:10.1200/JCO.2009.26.6213

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Article

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2010

Liu Yanhong, Shete Sanjay, Etzel Carol J, Scheurer Michael, Alexiou George, Armstrong Georgina, Tsavachidis Spyros, Liang Fu-Wen, Gilbert Mark, Aldape Ken, Armstrong Terri, Houlston Richard, Hosking Fay, Robertson Lindsay, Xiao Yuanyuan, Wiencke John, Wrensch Margaret, Andersson Ulrika, Melin Beatrice S, Bondy Melissa

Abstract excerpt

PURPOSE: Glioblastoma (GBM) is the most common and aggressive type of glioma and has the poorest survival. However, a small percentage of patients with GBM survive well beyond the established median. Therefore, identifying the genetic variants that influence this small number of unusually long-term survivors may provide important insight into tumor biology and treatment. PATIENTS AND METHODS: Among 590 patients...

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Identifiers

PMID: 20368557
DOI: 10.1200/JCO.2009.26.6213
PMCID: PMC2881725

Genes

HMGA2
LIG4
RTEL1
BTBD2
STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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