Article
High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants.
Atherosclerosis - 1 Sept 2008
van Acker Bernadette A C, Botma Gert-Jan, Zwinderman Aeilko H, Kuivenhoven Jan Albert, Dallinga-Thie Geesje M, Sijbrands Eric J G, Boer Jolanda M A, Seidell Jacob C, Jukema J Wouter, Kastelein John J P, Jansen Hans, Verhoeven Adrie J M
Abstract excerpt
Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties. We hypothesized that CETP and HL synergistically affect HDL cholesterol and atherosclerotic risk. To test our hypothesis, we analysed the genotype frequencies of CETP Taq1B (rs708272) and LIPC-514C/T (rs1800588) polymorphisms in male coronary artery disease patients...
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