Article
Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease.
Human genetics - 1 May 2007
McCaskie Pamela A, Beilby John P, Chapman Caroline M L, Hung Joseph, McQuillan Brendan M, Thompson Peter L, Palmer Lyle J
Abstract excerpt
High-density lipoprotein cholesterol (HDL-C) is a known inverse predictor of coronary heart disease (CHD) and is thus a potential therapeutic target. Cholesteryl ester transfer protein (CETP) is a key protein in HDL-C metabolism such that elevated CETP activity is associated with lower HDL-C. Currently available HDL-C raising drugs are relatively ineffective and evidence suggesting the role of CETP in HDL-C...
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