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Article

Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome.

Arthritis and rheumatism - 1 Jan 2008

Nedjai Belinda, Hitman Graham A, Yousaf Nasim, Chernajovsky Yuti, Stjernberg-Salmela Susanna, Pettersson Tom, Ranki Annamari, Hawkins Philip N, Arkwright Peter D, McDermott Michael F, Turner Mark D

Abstract excerpt

OBJECTIVE: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene. The cellular mechanisms by which mutations in this gene trigger inflammation are currently unclear. Because NF-kappaB is the major intracellular signaling component inducing secretion of proinflammatory cytokines, we sought to determine...

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PMID: 18163488
DOI: 10.1002/art.23123

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome.PMID 18163488Read ↗

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