Article
Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation.
Arthritis and rheumatism - 1 Sept 2005
Yousaf Nasim, Gould David J, Aganna Ebun, Hammond Linda, Mirakian Rita M, Turner Mark D, Hitman Graham A, McDermott Michael F, Chernajovsky Yuti
Abstract excerpt
OBJECTIVE: To investigate the molecular consequences of expressing mutated forms of tumor necrosis factor receptor I (TNFRI) as found in patients with TNFR-associated periodic syndrome (TRAPS). METHODS: We cloned and expressed full-length wild-type (WT) and T50K and P46L variants of TNFRI using a new tightly regulated doxycycline-dependent expression system. This system enabled the study of molecular interactions...
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