Article
Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients.
Cellular immunology - 1 Jan 2011
Nedjai Belinda, Hitman Graham A, Church Leigh D, Minden Kirsten, Whiteford Margo L, McKee Shane, Stjernberg Susanna, Pettersson Tom, Ranki Annamari, Hawkins Philip N, Arkwright Peter D, McDermott Michael F, Turner Mark D
Abstract excerpt
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene which encodes the tumor necrosis factor (TNF) receptor, TNFR1. We investigated the effect of three high penetrance and three low penetrance TNFRSF1A mutations upon NF-κB transcription factor family subunit activity, and the resulting impact upon secretion...
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