Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010

Simon Anna, Park Heiyoung, Maddipati Ravikanth, Lobito Adrian A, Bulua Ariel C, Jackson Adrianna J, Chae Jae Jin, Ettinger Rachel, de Koning Heleen D, Cruz Anthony C, Kastner Daniel L, Komarow Hirsh, Siegel Richard M

Abstract excerpt

TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases. TNFR-associated periodic syndrome (TRAPS, OMIM 142680) is an autosomal dominant autoinflammatory disorder characterized by prolonged attacks of fevers, peritonitis, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Autoinflammatory Diseases
Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to p38 Mitogen-Activated Protein Kinases

Share to Receptors, Tumor Necrosis Factor, Type I

Source

Open in PubMed Open full text

Identifiers

PMID: 20457915
DOI: 10.1073/pnas.0914118107
PMCID: PMC2906866

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20457915-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome.PMID 20457915Read ↗

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).Semantic proximity Read ↗

Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndromeSemantic proximity Read ↗

TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1.Semantic proximity Read ↗

Revisiting TNF Receptor-Associated Periodic Syndrome (TRAPS): Current Perspectives.Semantic proximity Read ↗

The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder.Semantic proximity Read ↗

Setting up TRAPS.Semantic proximity Read ↗

Candidate genes in patients with autoinflammatory syndrome resembling tumor necrosis factor receptor-associated periodic syndrome without mutations in the TNFRSF1A gene.Semantic proximity Read ↗

TNFRSF1A mutations and autoinflammatory syndromes.Semantic proximity Read ↗

the tumour necrosis factor receptor-associated periodic syndrome: current conceptsSemantic proximity Read ↗

Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line.Semantic proximity Read ↗

Gene expression profile in TNF receptor-associated periodic syndrome reveals constitutively enhanced pathways and new players in the underlying inflammation.Semantic proximity Read ↗

TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.