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Article

Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome.

Arthritis and rheumatism - 1 Feb 2009

Nedjai Belinda, Hitman Graham A, Quillinan Niamh, Coughlan Robert J, Church Leigh, McDermott Michael F, Turner Mark D

Abstract excerpt

OBJECTIVE: Tumor necrosis factor receptor (TNFR)-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSF1A gene. Unlike other autoinflammatory diseases in which anti-TNF therapy is largely a successful treatment option, therapy with the anti-TNF drug infliximab is often ineffective in patients with TRAPS. Moreover, in certain cases, infliximab...

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Identifiers

PMID: 19180495
DOI: 10.1002/art.24294

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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