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PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study.

Diabetes - 1 Apr 2008

Lai Chao-Qiang, Tucker Katherine L, Parnell Laurence D, Adiconis Xian, García-Bailo Bibiana, Griffith John, Meydani Mohsen, Ordovás José M

Abstract excerpt

OBJECTIVE: Individuals with type 2 diabetes exhibit higher DNA damage and increased risk of cardiovascular disease (CVD). However, mechanisms underlying the association between DNA damage and development of type 2 diabetes and CVD are not understood. We sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitochondrial oxidative...

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Identifiers

PMID: 18162502
DOI: 10.2337/db07-1238
PMCID: PMC2519884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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