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Article

Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.

European heart journal - 1 Mar 2004

Dhamrait Sukhbir S, Stephens Jeffrey W, Cooper Jacqueline A, Acharya Jayshree, Mani Ali R, Moore Kevin, Miller George J, Humphries Steve E, Hurel Steven J, Montgomery Hugh E

Abstract excerpt

BACKGROUND: Oxidative stress reduces total antioxidant status (TAOS) and is implicated in atherogenesis. Mitochondrial uncoupling protein 2 (UCP2) negatively regulates reactive oxygen species generation. The UCP2 gene demonstrates a common functional promoter variant (-866G>A). METHODS AND RESULTS: Amongst 465 diabetic men (age 61.7 +/- 13.3 years), an association of the UCP2-866A allele with significantly lower...

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Source

Identifiers

PMID: 15039126
DOI: 10.1016/j.ehj.2004.01.007

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.PMID 15039126Read ↗

Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes.Semantic proximity Read ↗

The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men.Semantic proximity Read ↗

The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women.Semantic proximity Read ↗

Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients.Semantic proximity Read ↗

The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction.Semantic proximity Read ↗

Uncoupling protein 2 -866G/A and uncoupling protein 3 -55C/T polymorphisms in young South African Indian coronary artery disease patients.Semantic proximity Read ↗

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic healthSemantic proximity Read ↗

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.Semantic proximity Read ↗

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism - 866 G/A in the promoter region is associated with type 2 diabetes mellitus among Kashmiri population of Northern India.Semantic proximity Read ↗

The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.Semantic proximity Read ↗

Association of uncoupling protein-2 -866G/A and Ala55Val polymorphisms with susceptibility to type 2 diabetes mellitus: A meta-analysis of case-control studies.Semantic proximity Read ↗

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