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Article

PGC-1alpha gene and physical activity in type 2 diabetes mellitus.

Exercise and sport sciences reviews - 1 Oct 2006

Franks Paul W, Loos Ruth J F

Abstract excerpt

Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative...

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Source

Identifiers

PMID: 17031255
DOI: 10.1249/01.jes.0000240021.92254.23

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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