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Article

Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype.

World journal of gastroenterology - 28 Dec 2007

Strauch Ulrike G, Obermeier Florian, Grunwald Nicole, Dunger Nadja, Rath Heiko C, Schölmerich Jurgen, Steinmeyer A, Zügel U, Herfarth H H

Abstract excerpt

AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA....

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Identifiers

PMID: 18161923
DOI: 10.3748/wjg.v13.i48.6529
PMCID: PMC4611292

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