Article

Single cell transcriptomic analyses reveal the impact of bHLH factors ATOH7 and Neurog2 on human retinal organoid development

2020-10-28

Abstract excerpt

The developing retina expresses multiple bHLH transcription factors. Their precise functions and interactions in uncommitted retinal progenitors remain to be fully elucidated. Here, we investigate the roles of bHLH factors ATOH7 and Neurog2 in developing human ES cell-derived 3D retinal organoids. Single cell transcriptome analyses identify three states of proliferating retinal progenitors: pre-neurogenic, neuroge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02de55c4-5e07-55db-b2f2-fe4472510a76
DOI: 10.1101/2020.10.27.358135

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptomic analyses reveal the impact of bHLH factors ATOH7 and Neurog2 on human retinal organoid developmentDOI 10.1101/2020.10.27.358135Read

Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid DevelopmentSemantic proximity Read

Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinasSemantic proximity Read

Neurog2 controls the leading edge of neurogenesis in the mammalian retina.Semantic proximity Read

Identification and characterization of human retinal stem cells capable of retinal regenerationSemantic proximity Read

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retinaSemantic proximity Read

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling developmentSemantic proximity Read

Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell levelSemantic proximity Read

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitroSemantic proximity Read

Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell levelSemantic proximity Read

Single-cell analysis reveals cellular heterogeneity and limits of marker-based assessment in retinal ganglion cell-enriched organoid culturesSemantic proximity Read

Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retinaSemantic proximity Read

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease mapSemantic proximity Read