Article
Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome.
Cell - 28 Dec 2007
Chekanova Julia A, Gregory Brian D, Reverdatto Sergei V, Chen Huaming, Kumar Ravi, Hooker Tanya, Yazaki Junshi, Li Pinghua, Skiba Nikolai, Peng Qian, Alonso Jose, Brukhin Vladimir, Grossniklaus Ueli, Ecker Joseph R, Belostotsky Dmitry A
Abstract excerpt
The exosome complex plays a central and essential role in RNA metabolism. However, comprehensive studies of exosome substrates and functional analyses of its subunits are lacking. Here, we demonstrate that as opposed to yeast and metazoans the plant exosome core possesses an unanticipated functional plasticity and present a genome-wide atlas of Arabidopsis exosome targets. Additionally, our study provides...
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