HIV Proteins Regulate Bone Marker Secretion and Transcription Factor Activity in Cultured Human Osteoblasts with Consequent Potential Implications for Osteoblast Function and Development

Abstract excerpt

A high incidence of decreased bone mineral density (BMD) has increasingly been associated with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB) cell lines were treated with HIV tat, HIV rev, HIV p55-gag, HIV gp120 and HTLV env (100 ng/ml, 24 h). Cells were then analyzed for calcium deposition, alkaline phosphatase (ALP) activity, and lipid levels using established methods....

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