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HIV‐1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFα activation

22 Jul 2008

Abstract excerpt

Several HIV-1 infected patients show bone loss and osteopenia/osteoporosis during the course of disease. The mechanisms underlying this degenerative process are largely unsettled and it has not been determined yet whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation. This study investigated the effects of HIV-1(IIIb) and HIV-1(ADA)...

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PMID: 18649336
DOI: 10.1002/jmv.21266

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