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Endogenous retrotransposon activity supports osteocyte function and links antiretroviral therapy to bone loss

2025-12-27

Abstract excerpt

Retrotansposable elements such as LINE-1 and HERV-K encode endogenous reverse transcriptases (RTs) with emerging roles in human biology. People living with HIV, particularly those receiving nucleoside reverse transcriptase inhibitor (NRTI)-based therapy, have increased risk of low bone mineral density (BMD), but the underlying mechanisms remain unclear. Here we show that endogenous RT activity, estimated by L1-Ta...

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Literature Corpus work
0e28f359-733b-50d9-8760-ff073b7d289d
DOI
10.64898/2025.12.27.696700
Open publication

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Endogenous retrotransposon activity supports osteocyte function and links antiretroviral therapy to bone lossDOI 10.64898/2025.12.27.696700
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