Article
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
The Journal of biological chemistry - 11 Oct 2013
Ferreira Elisabeth, Porter Ryan M, Wehling Nathalie, O'Sullivan Regina P, Liu Fangjun, Boskey Adele, Estok Daniel M, Harris Mitchell B, Vrahas Mark S, Evans Christopher H, Wells James W
Abstract excerpt
Bone marrow contains mesenchymal stem cells (MSCs) that can differentiate along multiple mesenchymal lineages. In this capacity they are thought to be important in the intrinsic turnover and repair of connective tissues while also serving as a basis for tissue engineering and regenerative medicine. However, little is known of the biological responses of human MSCs to inflammatory conditions. When cultured with...
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