Article
Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014
Chen Weiqiang, Foo Suan-Sin, Rulli Nestor E, Taylor Adam, Sheng Kuo-Ching, Herrero Lara J, Herring Belinda L, Lidbury Brett A, Li Rachel W, Walsh Nicole C, Sims Natalie A, Smith Paul N, Mahalingam Suresh
Abstract excerpt
Arthritogenic alphaviruses including Ross River virus (RRV), Sindbis virus, and chikungunya virus cause worldwide outbreaks of musculoskeletal disease. The ability of alphaviruses to induce bone pathologies remains poorly defined. Here we show that primary human osteoblasts (hOBs) can be productively infected by RRV. RRV-infected hOBs produced high levels of inflammatory cytokine including IL-6. The RANKL/OPG...
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