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Article

Distinct roles and regulations for HoxD genes in metanephric kidney development.

PLoS genetics - 1 Dec 2007

Di-Poï Nicolas, Zákány József, Duboule Denis

Abstract excerpt

Hox genes encode homeodomain-containing proteins that control embryonic development in multiple contexts. Up to 30 Hox genes, distributed among all four clusters, are expressed during mammalian kidney morphogenesis, but functional redundancy between them has made a detailed functional account difficult to achieve. We have investigated the role of the HoxD cluster through comparative molecular embryological...

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Animals, Newborn
Gene Targeting
Genes, Homeobox
Kidney Tubules
Lac Operon
Mesoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Kidney Diseases

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Identifiers

PMID: 18159948
DOI: 10.1371/journal.pgen.0030232
PMCID: PMC2151092

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