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Article

Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development.

Pediatric research - 1 Nov 2017

Song Renfang, Lopez Maria Luisa S Sequeira, Yosypiv Ihor V

Abstract excerpt

BackgroundWe tested the hypothesis that Foxd1, a transcription factor essential for normal kidney development, is an upstream regulator of the renin-angiotensin system (RAS) during ureteric bud (UB)-branching morphogenesis.MethodsUB branching, RAS gene, and protein expression were studied in embryonic mouse kidneys. RAS mRNA expression was studied in mesenchymal MK4 cells.ResultsThe number of UB tips was reduced...

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Source

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Identifiers

PMID: 28665931
DOI: 10.1038/pr.2017.157
PMCID: PMC5645264

Genes

ACE
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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