Article
C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA(Sec).
Nucleic acids research - 1 Feb 2011
Sherrer R Lynn, Araiso Yuhei, Aldag Caroline, Ishitani Ryuichiro, Ho Joanne M L, Söll Dieter, Nureki Osamu
Abstract excerpt
O-Phosphoseryl-tRNA kinase (PSTK) is the key enzyme in recruiting selenocysteine (Sec) to the genetic code of archaea and eukaryotes. The enzyme phosphorylates Ser-tRNA(Sec) to produce O-phosphoseryl-tRNA(Sec) (Sep-tRNA(Sec)) that is then converted to Sec-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase. Earlier we reported the structure of the Methanocaldococcus jannaschii PSTK (MjPSTK) complexed with AMPPNP. This study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.