Article
Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2008
Javorovic Miran, Wilde Susanne, Zobywalski Anke, Noessner Elfriede, Lennerz Volker, Wölfel Thomas, Schendel Dolores J
Abstract excerpt
Tumor cells that show downregulation of their tumor-associated antigens (TAAs) may be able to escape immune-mediated elimination. Therefore, efficient vaccine strategies attempt to target multiple TAAs simultaneously. This is easily achieved in dendritic cell (DC)-based vaccines by introducing antigens in the form of RNA. Although insufficient message may hinder adequate expression of individual TAAs when using...
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