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Cancer immunotherapy with mRNA‐transfected dendritic cells

5 May 2004

Abstract excerpt

Bone marrow-derived dendritic cells (DCs) are the most potent antigen-presenting cells capable of activating naïve T cells. Loading DCs ex vivo with tumor antigens can stimulate potent antitumor immunity in tumor-bearing mice. This review describes the use of mRNA-encoded tumor antigens as a form of antigen loaded onto DCs, including our early experience from clinical trials in urological cancers. Transfection of...

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PMID: 15233739
DOI: 10.1111/j.0105-2896.2004.00139.x

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