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A synthetic DNA template for fast manufacturing of versatile single epitope mRNA

17 Aug 2022

Abstract excerpt

A flexible, affordable, and rapid vaccine platform is necessary to unlock the potential of personalized cancer vaccines in order to achieve full clinical efficiency. mRNA cancer vaccine manufacture relies on the rigid sequence design of multiepitope constructs produced by laborious bacterial cloning and time-consuming plasmid preparation. Here, we introduce a synthetic DNA template (SDT) assembly process, which...

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PMID: 36159589
DOI: 10.1016/j.omtn.2022.08.021

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