Article
Clonal cytotoxic T cells in myeloma.
Leukemia & lymphoma - 1 Oct 2003
Sze Daniel M Y, Brown Ross D, Yuen Edna, Gibson John, Ho Joy, Raitakari Maria, Basten Antony, Joshua Douglas E, Fazekas de St Groth Barbara
Abstract excerpt
Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an improved prognosis. This review aims to describe the various ways...
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