Article
The occurrence of Brugada syndrome and isolated cardiac conductive disease in the same family could be due to a single SCN5A mutation or to the accidental association of both diseases.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Jan 2008
Six Isabelle, Hermida Jean-Sylvain, Huang Hai, Gouas Laetitia, Fressart Véronique, Benammar Nawal, Hainque Bernard, Denjoy Isabelle, Chahine Mohamed, Guicheney Pascale
Abstract excerpt
AIMS: The distinct cardiac arrhythmia diseases, Brugada syndrome (BS) and isolated cardiac conduction disease (ICCD) are caused by heterozygous mutations in the SCN5A gene. Previous studies have demonstrated an intriguing association between ICCD and BS with the same mutation in the SCN5A gene. METHODS AND RESULTS: The proband of a multigenerational family presented BS and a familial history of sudden death. We...
Topics
- Adult
- Aged
- Arrhythmias, Cardiac
- Brugada Syndrome
- Electrocardiography
- Female
- Heart Conduction System
- Humans