Article
A hemA mutation renders Salmonella typhimurium avirulent in mice, yet capable of eliciting protection against intravenous infection with S. typhimurium.
Microbial pathogenesis - 1 Oct 1991
Benjamin W H, Hall P, Briles D E
Abstract excerpt
The hemA mutation reduces the virulence of Salmonella typhimurium for mice by at least 10(7)-fold, as measured by change in LD50. The hemA mutation does not appear to affect killing of salmonella in mice. The salmonella with the hemA mutation persist in the spleen and liver for 2 to 3 weeks following intravenous injection. The most likely effect of the hemA mutation is to block, or retard, growth of S....
Topics
- Aldehyde Oxidoreductases
- Animals
- Bacterial Proteins
- Female
- Liver
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Salmonella Infections, Animal
- Salmonella typhimurium