Genetically stable temperature-sensitive mutants of Salmonella typhi induce protection in mice.

doi:10.1016/0264-410x(93)90166-u

Back to search

Article

Genetically stable temperature-sensitive mutants of Salmonella typhi induce protection in mice.

Vaccine - 1 Nov 1993

Hooke A M, Cerquetti M C, Zeligs B J, Wang Z, Hoberg K, Bellanti J A

Abstract excerpt

Temperature-sensitive (ts) mutants of Salmonella typhi were isolated following treatment with nitrosoguanidine, and characterized with respect to cut-off temperature, ts phenotype and reversion frequency. Linkage of the ts mutations to selectable chromosomal markers was established by generalized...

Topics

Animals
Immunization
Male
Mice
Mice, Inbred BALB C
Mutation
Phenotype
Salmonella typhi
Sensitivity and Specificity
Temperature
Typhoid Fever
Typhoid-Paratyphoid Vaccines
Vaccines, Attenuated

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.