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Salmonella DNA adenine methylase mutants elicit protective immune responses to homologous and heterologous serovars in chickens.

Infection and immunity - 1 Dec 2001

Dueger E L, House J K, Heithoff D M, Mahan M J

Abstract excerpt

Salmonella DNA adenine methylase (Dam) mutants that lack or overproduce Dam are highly attenuated for virulence in mice and confer protection against murine typhoid fever. To determine whether vaccines based on Dam are efficacious in poultry, a Salmonella Dam(-) vaccine was evaluated in the protection of chicken broilers against oral challenge with homologous and heterologous Salmonella serovars. A Salmonella...

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Identifiers

PMID: 11705984
DOI: 10.1128/IAI.69.12.7950-7954.2001
PMCID: PMC98898

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